Homepage 2017-12-15T03:43:13+00:00

Our Mission

GeneSpark.org is an international non-profit foundation focused on the advancement of drug treatments for reversible Intellectual Disability (ID) disorders, specifically those arising from a gene deletion or mutation. Our initial focus is on Kleefstra syndrome (KS) and related ID disorders that have a potentially synergistic approach to drug development. Learn more

Fundraising & Research Progress

  • Over $1,200,000 raised to date
  • Three funded drug screening projects currently under way in the United States, Canada and The Netherlands
  • Kleefstra Syndrome drug “hit” identified and currently under further investigation

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Highlighted News

  • December 22, 2017 (Upcoming Webinar): Pharmacogenetics – Using Genetics To Improve Drug Effectiveness

    Did you know that the same drug can have a different affect on different people based on their genetic profile? Join us on December 22nd as we discuss how this knowledge can help us improve drug effectiveness – especially for those with Kleefstra syndrome. Q&A to follow discussion.

  • November 14, 2017: GeneSpark Second Annual Benefit

    Genespark hosted its second Annual Benefit in support of new drug therapies for Intellectual Disability disorders. With the wonderful support of our event sponsors and generous donations on the night of the event, we raised over $300,000!

  • November 10, 2017 (Past Webinar): Kleefstra Syndrome and Mental Health

    Learn about the relationship between mental health and Kleefstra syndrome, including the issue of regression. View the recorded webinar or download the slides (PDF).

  • October 7-15, 2017: Second Annual Kleefstra Syndrome Global “Walk & Roll”

    GeneSpark hosted its second annual global Walk & Roll. People from around the world participated in planning a walk in their own community to raise awareness about Kleefstra Syndrome. At the close of the event, our combined efforts raised close to $100,000! A huge thank you to all participants and congratulations on another great year.

  • September 20, 2017 (Past Webinar): Drug Repurposing – How A Drug Approved For One Disease Can Be Effectively Used To Treat Another

    Learn about the opportunity to take drugs already approved for one illness and repurpose them to a new target illness. In this webinar, we discussed why this is a viable strategy for Kleefstra Syndrome in addition to why additional testing is required. View the recorded webinar or download the slides (PDF).

  • August 8, 2017 (Past Webinar): Drug “Hit” Identified In KS Screening Using iPSC

    Learn about the exciting drug “hit” identified by our Netherlands research partner using iPSC technology. This is likely the first time in history that a specific compound has been shown to improve or reverse Kleefstra Syndrome in a lab environment. View the recorded webinar or download the slides (PDF).